研究論文・総説・知的財産権など

[2026]
■Narimichi, M., Komaki, Y., Suzuki, T. Ibuki, Y.
DNA repair-associated nucleases induce double-strand breaks following sequential exposure to UVA1 and UVB.
Photochem Photobiol Sci. 25(6):667-678 (2026)

[2025]
■Komaki, Y., Ibuki, Y.
Cigarette sidestream smoke-induced cellular senescence and the protective role of histone H2AX.
Toxicol In Vitro. 106076 (2025)

■Ito, R., Komaki, Y., Ibuki, Y.
Increased matrix metalloproteinase-1 expression by coexposure to UVA and cigarette sidestream smoke and contribution of histone acetylation.
Genes Environ. 47(1):2(2025)

■Suzuki, T., Komaki, Y., Amano, M., Ando, S., Shobu, K., Ibuki, Y
Faulty gap filling in nucleotide excision repair leads to double-strand break formation in senescent cells.
J. Invest. Dermatol. 145(1):32-41 (2025)

■Nishimura, A., Ogata, S., Tang, X., Hengphasatporn, K., Umezawa, K., Sanbo, M., Hirabayashi, M., Kato, Y., Ibuki, Y., Kumagai, Y., Kobayashi, K., Kanda, Y., Urano, Y., Shigeta, Y., Akaike, T., Nishida, M.
Polysulfur-based bulking of dynamin-related protein 1 prevents ischemic sulfide catabolism and heart failure in mice.
Nat. Commun. 16(1):276.(2025)

[2024]
■Nishimura, A., Zhou, L., Kato, Y., Mi, X., Ito, T., Ibuki, Y., Kanda, Y., Nishida, M.
Supersulfide prevents cigarette smoke extract-induced mitochondria hyperfission and cardiomyocyte early senescence by inhibiting Drp1-filamin complex formation.
J. Pharmacol. Sci. 154(2):127-135 (2024)

[2023]
■K. Hirakawa, N. Kishimoto, Y. Nishimura, Y. Ibuki, M. Fuki, S. Okazaki
Protein photodamaging activity and photocytotoxic effect of an axial-connecting　phosphorus(V)porphyrin trimer.
Chem. Res. Toxicol. 36(10), 1622-1630 (2023)

■Y. Komaki, S. Ono, T. Okuya, Y. Ibuki
Glucose starvation impairs NER and γ-H2AX after UVB irradiation.
Toxicol In Vitro. 86:105503 (2023)

[2022]
■Y. Kato, K. Nishiyama, J. Man Lee, Y. Ibuki, Y. Imai, T. Noda, N. Kamiya, T. Kusakabe, Y. Kanda, M. Nishida.
TRPC3-Nox2 protein complex formation increases the risk of SARS-CoV-2 spike protein-induced cardiomyocyte dysfunction through ACE2 upregulation.
Int. J. Mol. Sci. 24(1), 102 (2022)

■M. Tanaka, Y. Komaki, T. Toyooka, Y. Ibuki

Butyrate enhances γ-H2AX induced by benzo[a]pyrene.
Chem. Res. Toxicol. 35(12), 2241-2251 (2022)

■Y. Komaki, K. Suganuma, Y. Ibuki
Inhibition of nuleotide excision repair and damage response signaling by dibromoacetonitrile: A novel genotoxicity mechanism of a water disfection byproduct.
J. Environ. Sci. 117, 305-314 (2022)

■Y. Komaki, Y. Ibuki
Inhibition of nuleotide excision repair and damage response signaling by dibromoacetonitrile: A novel genotoxicity mechanism of a water disfection byproduct.
J. Hazard Mater. 423(Pt B):127194 (2022)

[2021]
■ M. Shikata, T. Toyooka, Y. Komaki, Y.Ibuki
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced Histone Acetylation via α7nAChR-Mediated PI3K/Akt Activation and Its Impact on γ-H2AX Generation.
Chem. Res. Toxicol. 34(12), 2512-2521 (2021)

■ Y. Ibuki, Y. Komaki, G. Yang, T. Toyooka
Long-wavelength UVA enhances UVB-induced cell death in cultured keratinocytes: DSB formation and suppressed survival pathway.
Photochem. Photobiol. Sci. 20(5) 639-652 (2021)

■ T. Fukuda, Y. Komaki, Y. Mori, Y.Ibuki
Low extracellular pH inhibits nucleotide excision repair.
Mutat. Res. 503374 (2021)

[2020]
■ R. Yamashita, Y. Komaki, G. Yang, Y.Ibuki
Cell line-dependent difference in glutathione levels affects the cigarette sidestream smoke-induced inhibition of nucleotide excision repair.
Mutat. Res. 858-860, 503273 (2020)

[2019]
■ G. Yang, Y. Komaki, Y.Ibuki
Formaldehyde inhibits UV-induced phosphorylation of histone H2AX.
Toxicol. In Vitro 61, 104687 (2019)

■ K. Hirakawa, A. Suzuki, D. Ouyang, S. Okazaki, Y. Ibuki, J. Nakazaki, H. Segawa.
Controlled Photodynamic Action of Axial Fluorinated DiethoxyP(V)tetrakis(p-methoxyphenyl)porphyrin through Self-Aggregation
Chem. Res. Toxicol. 32, 1638 (2019)

■ Komaki Y, Simpson AM, Choe JK, Pinney MM, Herschlag D, Chuang YH, Mitch WA.
Serum electrolytes can promote hydroxyl radical-initiated biomolecular damage from inflammation. .
Free Radic Biol Med. ;141:475-482 (2019). doi: 10.1016/j.freeradbiomed.2019.07.023.

■ K. Nishiyama, T. Numaga-Tomita, Y. Fujimoto, T. Tanaka, C. Toyama, A. Nishimura, T. Yamashita, N. Matsunaga, S. Koyanagi, Y.T. Azuma, Y. Ibuki, K. Uchida, S. Ohdo, M. Nishida.
Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes.
Br J Pharmacol. 176(18), 3723-3738 (2019). doi: 10.1111/bph.14777.

[2018]
■ G. Yang, Y. Komaki, Y.Ibuki
Aldehyde-mediated protein degradation is responsible for the inhibition of nucleotide excision repair by cigarette sidestream smoke
Mutat. Res. doi: 10.1016/j.mrgentox.2018.08.004

■ Y. Komaki, A.M. Simpson, J.K. Choe, M.J. Plewa, W.A. Mitch
Chlorotyrosines versus Volatile Byproducts from Chlorine Disinfection during Washing of Spinach and Lettuce.
Environ. Sci. Technol. doi: 10.1021/acs.est.8b03005.

■　 T. Toyooka, Y. Yanagiba, Y. Ibuki, RS. Wang
Trichloroethylene exposure results in the phosphorylation of histone H2AX in a human hepatic cell line through cytochrome P450 2E1-mediated oxidative stress.
J. Appl. Toxicol. doi: 10.1002/jat.3632.

■　 K. Hirakawa, D. Ouyang, Y. Ibuki, S. Hirohara, S. Okazaki, E. Kono, N. Kanayama, J. Nakazaki, H. Segawa
Photosensitized Protein-Damaging Activity, Cytotoxicity, and Antitumor Effects of P(V)porphyrins Using Long-Wavelength Visible Light through Electron Transfer.
Chem. Res. Toxicol. 31(5):371-379 (2018). doi: 10.1021/acs.chemrestox.8b00059.

■　 G. Yang, Y. Ibuki
α,β-Unsaturated Aldehyde-Induced Delays in Nucleotide Excision Repair and the Contribution of Reactive Oxygen Species.
Chem. Res. Toxicol. 31(2):145-155 (2018) doi: 10.1021/acs.chemrestox.7b00304.

■　 G. Yang, Y. Ibuki
Cigarette sidestream smoke delays nucleotide excision repair: inhibited accumulation of repair proteins at DNA lesions.
Carcinogenesis. 39(1):56-65 (2018). doi: 10.1093/carcin/bgx109.

[2017]
■　 X. Zhao, T. Toyooka, Y. Ibuki
Silver nanoparticle-induced phosphorylation of histone H3 at serine 10 is due to dynamic changes in actin filaments and the activation of Aurora kinases..
Toxicol Lett. 2017 May 9. pii: S0378-4274(17)30186-8. doi: 10.1016/j.toxlet.2017.05.009.

■　 T. Kato, T. Toyooka, Y. Ibuki, S. Masuda, M. Watanabe, Y. Totsuka
Effect of physicochemical character differences on the genotoxic potency of kaolin.
Genes Environ. 39:12. eCollection (2017).

■　 T. Toyooka, Y. Yanagiba, M. Suda, Y. Ibuki, RS. Wang
1,2-Dichloropropane generates phosphorylated histone H2AX via cytochrome P450 2E1-mediated metabolism.
Toxicol Lett. 272, 60-67 (2017).

■　 B. C. Nelson, C. W. Wright, Y. Ibuki, M. Moreno-Villanueva, H. L. Karlsson, G. Hendriks, C. M. Sims, N. Singh, S. H. Doak
Emerging Metrology for High Throughput Nanomaterial Genotoxicology
Mutagenesis 32(1), 215-232 (2017).

[2016]
■　X. Zhao, F. Takabayashi, Y. Ibuki
Coexposure to silver nanoarticles and ultraviolet A synergisticaly enhances the phosphorylation of histone H2AX.
J. Photochem. Photobiol. B. 162 213-222 (2016).

■　伊吹裕子
化学物質によるヒストン修飾と遺伝毒性
Bio Clinica 31(5) 93-96 (2016)

■　伊吹裕子
太陽紫外線の生体影響　日本光生物学協会　編　朝倉書店
光と生命の事典　294－295　2016年2月

[2015]
■　X. Zhao, G. Yang, T. Toyooka, Y. Ibuki
New mechanism of γ-H2AX generation: Surfactant-induced actindisruption causes deoxyribonuclease I translocation to the nucleusand forms DNA double-strand breaks
Mutat Res. 794, 1-7 (2015).

■　Y. Ibuki, M. Shikata, T. Toyooka
γ-H2AX is a sensitive marker of DNA damage induced by metabolically activated 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Toxicol. in vitro. 29, 1831-8 (2015).

■　X. Zhao, T. Toyooka, T. Kubota, G. Yang, Y. Ibuki
γ-H2AX induced by linear alkylbenzene sulfonates is due to deoxyribonuclease-1 translocation to the nucleus via actin disruption.
Mutat Res. 777, 33-42 (2015).

■　X. Zhao and Y. Ibuki
Evaluating the toxicity of Ag nanoparticles by detecting phosphorylation of histone H3 in combination with flow cytometry side-scattered light.
Environ. Sci. Technol. 49, 5003-12 (2015).

■　Y. Ibuki and T. Toyooka
Evaluation of chemical phototoxicity focusing on phosphorylated histone H2AX.
J. Radiat. Res. 56, 220-228 (2015)

[2014]
■　I. Yoshida and Y. Ibuki
Formaldehyde-induced histone H3 phosphorylation via JNK and the expression of proto-oncogenes.
Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis 770, 9-18 (2014)

■　X. Fang, N. Ide, S. Higashi, Y. Kamei, T. Toyooka, Y. Ibuki, K. Kawai, H. Kasai, K. Okamoto, S. Arimoto-Kobayashi, T. Negishi.
Somatic cell mutations caused by 365 nm LED-UVA due to DNA double-strand breaks through oxidative damage.
Photochem. Photobiol. Sci. 13. 1338-46 (2014)

■　X. Zhao, T. Toyooka, and Y. Ibuki
Silver ions enhance UVB-induced phosphorylation of histone H2AX.
Environ. Mol. Mutagen. 55, 556-565 (2014)

■　Y. Ibuki
Histone modifications induced by chemicals and photogenotoxicity
Genes and Environment 36, 111-117 (2014)

■　T. Kubota, T. Toyooka, X. Zhao and Y. Ibuki
Phosphorylation of histone H2AX generated by linear alkylbenzene sulfonates and its suppression by UVB exposure.
Photochemistry and Photobiology 90, 845-852 (2014)

■　Y.Ibuki, T. Toyooka, X. Zhao and I. Yoshida
Cigarette sidestream smoke induces histone H3 phosphorylation via JNK and PI3K/Akt pathways, leading to the expression of proto-oncogenes.
Carcinogenesis 35, 1228-1237(2014)

■　豊岡達士、伊吹裕子
ヒストンH2AXのリン酸化に着目した光毒性評価
放射線生物研究 49, 14-25 (2014)

[2013]
■　X. Zhao, T. Toyooka and Y. Ibuki
Synergistic bactericidal effect by combined exposure to Ag nanoparticles and UVA.
Science of the Total Environment 458-460, 54-62 (2013)

■　T.Kubota, T. Toyooka and Y. Ibuki
Nonylphenol polyethoxylates degraded by three different wavelengths of UV and their genotoxic change-detected by generation of γ-H2AX.
Photochemistry and Photobiology 89, 461-467 (2013)

■　T. Toyooka, T. Kubota and Y. Ibuki
UVB irradiation changes genotoxic potential of nonylphenol polyethoxylates γ-remarkable generation of -H2AX with degradation of chemical structure.
Mutagenesis 28, 7-14, (2013)

[2012]
■　T. Toyooka, T.Shinmen, Arts J.M. and Y. Ibuki
Dual effects of N-acetyl-L-cysteine dependent on NQO1 activity: suppressive or promotive of 9,10-phenanthrenequinone-induced toxicity
Toxicology and Applied Pharmacology 264, 404-412 (2012)

■　Y. Toduka, T. Toyooka, T. and Y. Ibuki
Flow cytometric evaluation of nanoparticles using side-scattered light and ROS-mediated fluorescence -correlation with genotoxicity.
Environmental Science & Technology 46:7629-7636 (2012)

■　Y. Sadzuka, M. Nagamine, T. Toyooka, Y. Ibuki and Sonobe T.
Beneficial effects of curcumin on antitumor activity and adverse reactions of doxorubicin.
International Journal of Pharmacology 432:42-49 (2012)

■　T. Toyooka, T. Amano and Y. Ibuki
Titanium dioxide particles phosphorylate histone H2AX independent of ROS production.
Mutation Research 742:84-91 (2012)

■　T. Toyooka, T. Kubota and Y. Ibuki
Nonylphenol polyethoxylates induce phosphorylation of histone H2AX.
Mutation Research 741: 57-64 (2012)

■　Y. Ibuki and T. Toyooka
Nanoparticle uptake measured by flow cytometry
Methods in Molecular Biology (chapter in Methods of Nanotoxicity) 46(14):7629-7636 (2012)

[2011]
■　T. Toyooka, M. Ishihama and Y. Ibuki
Phosphorylation of histone H2AX is a powerful tool for detecting chemical photogenotoxicity.
Journal of Investigative Dermatology 131:1313-1321 (2011)

[2010]
■　Y. Ibuki, M. Akaike and T. Toyooka
PI3-kinase/Akt pathway mediates expression of p53 after UVB irradiation.
Genes and Environment 32: 85-91 (2010)

■　G. Ohnuki, T. Toyooka and Y. Ibuki
UVB in solar-simulated light causes formation of BaP-photoproducts capable of generating phosphorylated histone H2AX.
Mutation Research 702: 70-77 (2010)

■　M. Koike, A. Koike, J. Sugasawa, T. Toyooka and Y. Ibuki
Dynamics of Ku80 in Living Hamster Cells with DNA Double-Strand Breaks Induced by Chemotherapeutic Drugs.
Journal of Veterinary Medical Science (2010)

■　M. Teranishi, T. Toyooka, T.Ohura, S. Masuda and Y. Ibuki
Benzo[a]pyrene exposed to solar-simulated light inhibits apoptosis and augments carcinogenicity.
Chemico-Biological Interactions 185: 4-11 (2010)

■　T. Amano, T. Toyooka and Y. Ibuki
Preparation of DNA-adsorbed TiO2 particles - augmentation of performance for environmental purification by increasing DNA adsorption by external pH regulation -
Science of the Total Environment 408: 480-485 (2010)

[2009]
■　T. Toyooka and Y. Ibuki
Cigarette sidestream smoke induces phosphorylated histone H2AX.
Mutation Research 676: 34-40 (2009)

■　T. Toyooka and Y. Ibuki
Histone deacetylase inhibitor, sodium butyrate enhances the cell-killing effect of psoralen plus UVA by attenuating nucleotide excision repair.
Cancer Research 69(8): 3492-3500 (2009)

■　T. Toyooka, T. Amano, H. Suzuki and Y. Ibuki
DNA can sediment TiO2 particles and decrease the uptake potential by mammalian cells.
Science of the Total Environment 407(7):2143-50 (2009)

[2008]
■　M. Ishihama, T. Toyooka and Y. Ibuki
Generation of phosphorylated histone H2AX by benzene metabolites.
Toxicology In Vitro 22(8):1861-18618 (2008)

■　Y. Ibuki, Y. Tani and T.Toyooka
UVB-exposed chlorinated bisphenol A generates phosphorylated histone H2AX in human skin cells.
Chemical Research in Toxicology 21(9):1770-1776 (2008)

■　H. Suzuki, T. Amano, T. Toyooka and Y. Ibuki.
Preparation of DNA-adsorbed TiO2 particles with high performance for purification of chemical pollutants.
Environmental Science & Technology 42(21): 8076-8082 (2008)

■　Y. Mutou, Y. Ibuki, Y. Terao, S. Kojima and R. Goto
Induction of apoptosis by UV-irradiated chlorinated bisphenol A in Jurkat cells.
Toxicology In Vitro 22(4):864-872 (2008).

■　T.Toyooka, G.Ohnuki and Y. Ibuki
Solar-simulated light-exposed benzo[a]pyrene induces phosphorylation of histone H2AX.
Mutation Research 650(2):132-139 (2008).

■　Y.Ibuki, M. Akaike, T.Toyooka and R.Goto
Akt-mediated intracellular oxidation after UVB irradiation suppresses apoptotic cell death induced by cell detachment and serum starvation.
Photochemistry & Photobiology 84(1):154-61 (2008).

■　伊吹裕子、豊岡達士: ヒストン高アセチル化状態における光増感処理による腫瘍殺傷方法：特願2008-307283

■　伊吹裕子、豊岡達士: 微細粒子分離方法：特願2008-161209

[2007]
■　T. Toyooka and Y. Ibuki
DNA damage induced by coexposure to PAHs and light. A mini review.
Environmental Toxicology & Pharmacology 23, 256-263 (2007).

■　Mutou Y, Ibuki Y and Kojima S
Immunomodulatory effects of ultraviolet B irradiation on atopic dermatitis in NC/Nga mice.
Photodermatology Photoimmunology & Photomedicine 23(4):135-44 (2007).

■　Y. Ibuki, M. Allanson, K.M. Dixon and V.E. Reeve
Radiation sources providing increased UVA/UVB ratios attenuate the apoptotic effects of the UVB waveband UVA-dose-dependently in hairless mouse skin.
Journal of Investigative Dermatology 127(9):2236-44 (2007).

■　H. Suzuki, T. Toyooka and Y. Ibuki
Simple and easy method to evaluate uptake potential of nanoparticles in mammalian cells using a flow cytometric light scatter analysis.
Environmental Science & Technology 41(8):3018-24 (2007).

■　Y. Ibuki, T. Toyooka, J. Shirahata, T. Ohura, and R.Goto
Water soluble fraction of solar-simulated light-exposed crude oil generates phosphorylation of histone H2AX in human skin cells under UVA exposure.
Environmental Molecular Mutagenesis 48(6):430-9(2007)

■　伊吹裕子、豊岡達士、鈴木浩史: DNA被覆無機基材及びそれを用いた有害物質除去材: 特願2007-038707

■　伊吹裕子、豊岡達士、石濱美緒：光毒性高感度検出方法及び光毒性検出用キット：特開2007-53926

[2006]
■　Y. Muto, Y. Ibuki, Y. Terao, S. Kojima and R. Goto
Change of estrogenic activity and release of chloride ion in chlorinated bisphenol a after exposure to ultraviolet B.
Biological & Pharmaceutical Bulletin 29, 2116-9 (2006).

■　T. Toyooka, Y. Ibuki, F. Takabayashi and R. Goto
Coexposure to benzo[a]pyrene and UVA induces DNA damage: First proof of double-strand breaks in a cell-free system.
Environmeantal Molecular Mutagenesis 47(1):38-47 (2006).

■　Y. Ibuki, T. Toyooka and R. Goto
Inhibition of apoptosis by menadione on exposure to UVA.
Cell Biology & Toxicology 22, 351-360 (2006).

■　T. Toyooka and Y. Ibuki
New method for testing phototoxicity of polycyclic aromatic hydrocarbons.
Environmental Science & Technology 40, 3603-3608 (2006).

■　Y. Ibuki, M. Akaike, T. Toyooka, T. Mori, T. Nakayama and R. Goto
Hydrogen peroxide is critical for UV-induced apoptosis inhibition.
Redox Report 11, 53-60 (2006).

■　Y. Mutou, Y. Ibuki, Y. Terao, S. Kojima and R. Goto
Chemical change of chlorinated bisphenol A by ultraviolet irradiation and cytotoxicity of their products on Jurkat cells.
Environmental Toxicology & Pharmacology 21, 283-289 (2006).

[2005]
■　T. Toyooka and Y. Ibuki
Coexposure to benzo[a]pyrene and UVA induces phosphorylation of histone H2AX.
FEBS Letters 579, 6338-6342(2005).

■　Y. Ibuki, H. Naitou, N. Ohashi and R. Goto
Proteome analysis of UV-B-induced anti-apoptotic regulatory factors.
Photochemistry & Photobiology 81, 823-829 (2005).

[2004]
■　T. Toyooka, Y. Ibuki, M. Koike, N. Ohashi, S. Takahashi and R. Goto
Coexposure to benzo[a]pyrene plus UVA induced DNA double strand breaks: visualization of Ku assembly in the nucleus having DNA lesions.
Biochemical & Biophysical Research Communications 322, 631-6 (2004).

■　Y. Ibuki, and R. Goto
Dysregulation of apoptosis by benzene metabolites and their relationshoips with carcinogenesis.
Biochimica et Biophysica Acta 1690, 11-21 (2004).

■　A. Takeda, H. Tamano, Y. Ibuki Change of zinc uptake under growth arrest and apoptosis.
Anticancer Research 24, 3869-3874 (2004).

■　R. Goto, T. Kubota, Y. Ibuki and A. Goto
Dysregulation of nonylphenol polyethoxylates by ultraviolet B irradiation and effects of their products on mammalian cultured cells.
Toxicology 202, 237-247 (2004).

■　H. Yoshida, M. Aika, A. Iki, Y. Ibuki and R. Goto
Fluctuation factors of ambient dose rates in the vicinity of Hamaoka nuclear power plant.
Radioisotopes 53, 405-413 (2004).

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